... 1-4^3.1

1 point is scored for each of the following: if the subject has ever smoked, is diabetic, has hypertension, has a history of cerebrovascular disease.

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.

... pericytic^3.2

Pericytes are closely associated with the basement membrane and act as supporting cells to the capillaries, regulating capillary tone, aiding in the immune response and regulating vascular development.

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.

... ATP^3.3

The cell's energy supply.

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.

... brain^4.1

Physiological blood flow is generally measured relative to the mass of tissue through which the blood passes. The conversion between the two is straightforward.

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.

... molecules^4.2

In the standard techniques, this would be the time of arrival of the earliest arriving contrast molecules in the capillary beds, in this context it is merely the arrival time of the earliest molecules in the voxel.

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.

... contrast^4.3

In terms of dynamic range, not contrast agent concentration.

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.

... region^5.1

NB, these regions would hold even in the pedantic case where there was an occlusion and the region was actually fed by collateral flow. It is just illustrative.

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.

... arteries^5.2

Note that left and right here are the observer's left and right, not anatomical.

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.

... TTM^5.3

The TTM has no fixed origin, therefore in order to make comparisons between individuals, the mean of the region formed by the 10 vascular territories is subtracted from the TTM images, then the regional territory means are calculated. Any global delays in arrival time will not be detected, but any differences between the regions will be apparent. The NMTT is not used here due to artefacts and inaccuracies introduced by high flow vessels.

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.

... subjects^5.4

It was believed that the cerebral blood flow would be so low in the AD subjects that a double-dose would be required to obtain reasonable contrast signal-time curves. This made no practical difference to the calculations.

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.

...=0.995^5.5

The numbers in the square brackets represent, in order, the numerator and denominator degrees of freedom.

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.

... level^6.1

The level at which one would would expect by chance a $\chi ^2$ value of that or greater 5% of the time.

.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.