Dr. Paul A. Bromiley


TINA is an open-source software environment designed to accelerate the process of image analysis research. It provides functionality in a wide variety of areas, from basic image processing to state-of-the-art medical image processing algorithms. It is the product of nearly 30 years of research by a large number of people at both the University of Manchester and, in the past, the University of Sheffield. I developed the TINA non-parametric image subtraction [flyer] and colour image segmentation algorithms, and contributed extensively to the cortical thickness measurement algorithm and the medical image registration and segmentation algorithms. I have also been web-master of the TINA website since 2003. Descriptions of the algorithms available in TINA, and instructions on how to use the software, can be obtained from the TINA Memos page.

In more recent work, in collaboration with the Max Planck Institute for Evolutionary Biology, I developed the TINA Geometric Morphometrics Toolkit. This ~50,000 lines of code application allows 3D volume rendering of CT datasets, and supports both manual and automatic annotation of landmark points on the images, massively accelerating the annotation process. Whilst the project ended in 2012, the software is still extensively used both within the institute and in other research groups around the world.

The TINA software is distributed under the lesser GPL licence, and is free for anyone to download, use and develop. The website usage statistics show an average of 500,000 hits and 200 downloads of the software per month. At this stage, it is difficult to estimate how many groups and individuals around the world are using the software. However, Google Scholar shows that it has been used in published research from, amongst others:

The University of Manchester;
The University of Central Lancashire;
The University of Wales;
The University of Newcastle;
The University of Witten/Herdecke, Germany;
The Albert-Ludwigs-University Freiburg, Freiburg, Germany;
The University Medical Center Hamburg-Eppendorf, Germany;
The Bogomoletz Institute of Physiology;
The Max Planck Institute for Evoultionary Biology, Germany;
The University of Vienna;
The Technion - Israel Institute of Technology;
The Tel-Aviv University, Israel;
The University of the Ryukyus, Japan;
The Kyoto University, Japan;
The University of Washington;
The Universidad Nacional de La Plata, Argentina.

Many of these publications use the software to perform various studies in genetics and proteomics e.g. analyzing the results of Western Blot tests.