Trends in Brain Volume Change with Normal Ageing

MIUA 2005, Bristol, U.K.

In order to measure cerebral atrophy due to neurodegenerative diseases, the major confounding factor of normal age-related atrophy must be taken into account. We describe a normalisation for this effect, based on measuring CSF volumes in MR images of 70 normal volunteers. We also investigate the regional distribution of the atrophy, and conclude that age-related cerebral atrophy occurs uniformly across the brain at coarse scales and obeys a Weibull cumulative distribution function.

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